ADAMTSL4

Across TCGA patient cohorts, ADAMTSL4 mutation is significantly associated with the RNA expression of many other genes, with 3,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL4-associated genes across cancer lineages are PRPF4, AZI2, and CDCA2. Each is linked with ADAMTSL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTSL4-to-partner and partner-to-ADAMTSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRPF4 grouped by ADAMTSL4-low versus ADAMTSL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL4→partner) and Y-score (partner→ADAMTSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRPF4 →	+0.427	+1.653	<.001	<.001	3	4
COAD	AZI2 →	+0.311	+2.605	.006	.005	3	4
UCEC	CDCA2 →	+0.620	+2.269	<.001	<.001	3	4
UCEC	SKA1 →	+0.511	+1.283	<.001	.005	3	3
UCEC	TYW3 →	+0.395	+2.365	<.001	<.001	3	3
UCEC	AP1G1 →	+0.405	+2.119	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

PRPF4 by ADAMTSL4 expression — UCEC

Explore this box plot interactively →