ADAMTSL4

Across TCGA patient cohorts, ADAMTSL4 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL4-associated genes across cancer lineages are 4E-BP1, eEF2, and EGFR_pY1068. Each is linked with ADAMTSL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTSL4-to-partner and partner-to-ADAMTSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ADAMTSL4-low versus ADAMTSL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL4→partner) and Y-score (partner→ADAMTSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.319	+3.087	<.001	<.001	3	3
UCEC	eEF2 →	+0.298	+2.222	.005	.009	3	2
COAD	EGFR_pY1068 →	-0.342	-3.157	.006	.018	3	2
UCEC	MEK1 →	+0.460	+2.273	<.001	<.001	3	2
UCEC	MSH6 →	-0.295	-1.280	.003	.049	3	2
UCEC	mTOR_pS2448 →	-0.172	-2.649	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

4E-BP1 by ADAMTSL4 expression — UCEC

Explore this box plot interactively →