ADAMTSL4

Across TCGA cell cohorts, ADAMTSL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,545 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAMTSL4-associated GO terms across cancer lineages are Regulation of cell-substrate junction organization, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with ADAMTSL4 in more than 10 cancer types. Because this analysis shows association rather than direction, both ADAMTSL4-to-partner and partner-to-ADAMTSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction organization grouped by ADAMTSL4-low versus ADAMTSL4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL4→partner) and Y-score (partner→ADAMTSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction organization →	+0.147	+1.906	<.001	<.001	3	11
BONE	Regulation of focal adhesion assembly →	+0.161	+1.376	<.001	<.001	3	10
BONE	Regulation of cell-substrate junction assembly →	+0.161	+1.376	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Establishment of protein localization to plasma membrane →	+0.112	+2.662	<.001	<.001	3	10
BONE	Regulation of cell-substrate adhesion →	+0.137	+1.882	<.001	<.001	3	10
STOMACH	Mannose metabolic process →	+0.136	+2.637	.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,545 associations by consensus.

Regulation of cell-substrate junction organization by ADAMTSL4 expression — BONE

Explore this box plot interactively →