ADAMTSL4

Across TCGA cell cohorts, ADAMTSL4 mutation is significantly associated with the RNA expression of many other genes, with 258 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTSL4-associated genes across cancer lineages are ACTL9, VSTM2A, and C12orf40. Each is linked with ADAMTSL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTSL4-to-partner and partner-to-ADAMTSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTL9 grouped by ADAMTSL4-low versus ADAMTSL4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL4→partner) and Y-score (partner→ADAMTSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACTL9 →	+0.010	+4.781	<.001	.003	3	2
OVARY	VSTM2A →	+0.086	+4.032	.001	.001	3	1
OVARY	C12orf40 →	+0.010	+3.181	<.001	.001	3	1
OVARY	PAPOLB →	+0.009	+3.376	.002	<.001	3	1
LARGE_INTESTINE	PES1 →	+0.487	+3.675	.006	<.001	3	1
LARGE_INTESTINE	MCAT →	+0.747	+3.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 258 associations by consensus.

ACTL9 by ADAMTSL4 expression — BREAST

Explore this box plot interactively →