ADAMTSL3

Across TCGA patient cohorts, ADAMTSL3 mutation is significantly associated with the RNA expression of many other genes, with 5,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL3-associated genes across cancer lineages are ERLIN1, ARHGAP11A, and ZC3H14. Each is linked with ADAMTSL3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTSL3-to-partner and partner-to-ADAMTSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERLIN1 grouped by ADAMTSL3-low versus ADAMTSL3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL3→partner) and Y-score (partner→ADAMTSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ERLIN1 →	+0.380	+3.782	<.001	<.001	3	5
UCEC	ARHGAP11A →	+0.673	+1.898	<.001	<.001	3	5
UCEC	ZC3H14 →	+0.314	+1.759	<.001	.001	3	4
UCEC	CORO2B →	-0.505	-2.726	<.001	<.001	3	4
UCEC	GLRX3 →	+0.353	+1.587	.001	<.001	3	4
UCEC	CHORDC1 →	+0.469	+2.871	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,928 associations by consensus.

ERLIN1 by ADAMTSL3 expression — LUAD

Explore this box plot interactively →