ADAMTSL3

Across TCGA patient cohorts, ADAMTSL3 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL3-associated genes across cancer lineages are cIAP, CD49b, and N-Ras. Each is linked with ADAMTSL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTSL3-to-partner and partner-to-ADAMTSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by ADAMTSL3-low versus ADAMTSL3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL3→partner) and Y-score (partner→ADAMTSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	cIAP →	+0.187	+2.348	.013	.020	3	4
STAD	CD49b →	+0.244	+3.459	.023	.004	3	4
UCEC	N-Ras →	-0.099	-1.419	.004	.005	3	3
STAD	FoxM1 →	+0.237	+3.169	.011	.017	3	3
STAD	ACVRL1 →	-0.157	-2.000	.039	.028	3	3
UCEC	Cyclin-B1 →	+0.654	+1.857	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

cIAP by ADAMTSL3 expression — BRCA

Explore this box plot interactively →