ADAMTSL3

Across TCGA cell cohorts, ADAMTSL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,242 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ADAMTSL3-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Alternative mRNA splicing, via spliceosome. Each is linked with ADAMTSL3 in more than 7 cancer types. Because this analysis shows association rather than direction, both ADAMTSL3-to-partner and partner-to-ADAMTSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by ADAMTSL3-low versus ADAMTSL3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL3→partner) and Y-score (partner→ADAMTSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.107	+1.123	.002	<.001	3	8
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.109	+1.123	.002	<.001	3	7
CNS	Alternative mRNA splicing, via spliceosome →	+0.044	+0.494	.003	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.062	-0.678	.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Energy derivation by oxidation of organic compounds →	+0.067	+0.794	.005	.002	2	7
OESOPHAGUS	Cytoplasmic translation →	+0.084	+1.081	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,242 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by ADAMTSL3 expression — OESOPHAGUS

Explore this box plot interactively →