ADAMTSL3

Across TCGA cell cohorts, ADAMTSL3 mutation is significantly associated with the RNA expression of many other genes, with 409 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTSL3-associated genes across cancer lineages are TSPO2, RNF133, and PRAMEF20. Each is linked with ADAMTSL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTSL3-to-partner and partner-to-ADAMTSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPO2 grouped by ADAMTSL3-low versus ADAMTSL3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL3→partner) and Y-score (partner→ADAMTSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TSPO2 →	+0.053	+3.865	.004	.006	3	2
BLOOD_Leukemia	RNF133 →	+0.034	+3.121	.006	.003	3	2
LUNG_SCLC	PRAMEF20 →	+0.153	+2.684	.003	.001	3	2
LARGE_INTESTINE	GBE1 →	+0.618	+3.087	.004	.006	3	2
LARGE_INTESTINE	RPP38 →	+0.409	+2.459	<.001	.006	3	2
LARGE_INTESTINE	DCK →	+0.572	+3.850	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 409 associations by consensus.

TSPO2 by ADAMTSL3 expression — SOFT_TISSUE

Explore this box plot interactively →