ADAMTSL1

Across TCGA patient cohorts, ADAMTSL1 mutation is significantly associated with the RNA expression of many other genes, with 6,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL1-associated genes across cancer lineages are UBE2MP1, KCNJ15, and FAM110B. Each is linked with ADAMTSL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTSL1-to-partner and partner-to-ADAMTSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2MP1 grouped by ADAMTSL1-low versus ADAMTSL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL1→partner) and Y-score (partner→ADAMTSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	UBE2MP1 →	+0.391	+3.286	.008	.007	3	4
LUAD	KCNJ15 →	-1.091	-2.415	<.001	.003	3	4
LUAD	FAM110B →	-0.533	-3.061	.001	<.001	3	4
LUAD	FENDRR →	-0.568	-2.137	.001	.001	3	4
CESC	PRDX2 →	+0.824	+3.351	.001	.005	3	4
UCEC	BUB1B →	+0.534	+1.882	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,432 associations by consensus.

UBE2MP1 by ADAMTSL1 expression — CESC

Explore this box plot interactively →