ADAMTSL1

Across TCGA patient cohorts, ADAMTSL1 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTSL1-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and AMPK_alpha. Each is linked with ADAMTSL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTSL1-to-partner and partner-to-ADAMTSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADAMTSL1-low versus ADAMTSL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL1→partner) and Y-score (partner→ADAMTSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.564	+3.601	<.001	.001	3	5
UCEC	ATM →	-0.499	-1.584	<.001	<.001	3	4
BRCA	AMPK_alpha →	-0.271	-3.136	.018	.020	3	3
UCEC	GAPDH →	+0.362	+2.000	.010	.002	3	3
SKCM	Ku80 →	+0.238	+2.807	.006	.002	3	3
UCEC	PCNA →	+0.207	+1.584	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Caspase-7-cleavedD198 by ADAMTSL1 expression — COAD

Explore this box plot interactively →