ADAMTSL1

Across TCGA cell cohorts, ADAMTSL1 mutation is significantly associated with the RNA expression of many other genes, with 1,445 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTSL1-associated genes across cancer lineages are DEPDC7, SLC22A25, and NPAP1. Each is linked with ADAMTSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTSL1-to-partner and partner-to-ADAMTSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC7 grouped by ADAMTSL1-low versus ADAMTSL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTSL1→partner) and Y-score (partner→ADAMTSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEPDC7 →	-0.990	-3.321	.003	.002	3	3
BLOOD_Lymphoma	SLC22A25 →	+0.053	+3.180	<.001	.004	3	2
BLOOD_Leukemia	NPAP1 →	+0.055	+2.644	<.001	.008	3	2
OVARY	SSMEM1 →	+0.063	+3.662	<.001	.009	3	2
STOMACH	TCTN3 →	+0.601	+3.070	.002	.008	3	2
STOMACH	SERAC1 →	+0.961	+3.137	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,445 associations by consensus.

DEPDC7 by ADAMTSL1 expression — LARGE_INTESTINE

Explore this box plot interactively →