ADAMTS7

Across TCGA pan-cancer cohorts, ADAMTS7 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ADAMTS7 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ADAMTS7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS7 expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

OV, STAD, and UCEC are the cancer types where ADAMTS7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.023	0.844	<.001	36	view →
STAD	DFS	Median	II,III,IV	1.000	0.333	.023	27	view →
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
SKCM	OS	Median	All	0.965	0.863	.007	11	view →
LIHC	OS	Median	All	0.105	0.774	.002	9	view →
KIRP	OS	Median	All	0.179	0.710	<.001	8	view →
UCS	DFS	Median	All	0.129	0.530	.035	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BLCA	DFS	Median	IV	0.122	0.469	.022	6	view →
LUAD	OS	Median	III,IV	0.235	0.677	.030	3	view →
SCLC	DFS	Median	II,III,IV	1.000	0.299	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

ADAMTS7–OV (OS)

Open the OV breakdown →