ADAMTS7

Across TCGA patient cohorts, ADAMTS7 mutation is significantly associated with the RNA expression of many other genes, with 2,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS7-associated genes across cancer lineages are PBK, RPL27P5, and C4orf46. Each is linked with ADAMTS7 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTS7-to-partner and partner-to-ADAMTS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by ADAMTS7-low versus ADAMTS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS7→partner) and Y-score (partner→ADAMTS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.808	+2.443	<.001	<.001	3	5
READ	RPL27P5 →	+0.370	+4.280	<.001	.007	3	4
LUSC	C4orf46 →	+0.409	+2.620	.008	.005	3	4
UCEC	MCAT →	+0.371	+2.949	<.001	<.001	3	4
UCEC	RRP7A →	+0.418	+2.432	<.001	<.001	3	4
UCEC	MAK16 →	+0.432	+2.662	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

PBK by ADAMTS7 expression — UCEC

Explore this box plot interactively →