ADAMTS7

Across TCGA cell cohorts, ADAMTS7 mutation is significantly associated with the RNA expression of many other genes, with 1,472 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS7-associated genes across cancer lineages are ZMYND8, CLUAP1, and INTS9. Each is linked with ADAMTS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS7-to-partner and partner-to-ADAMTS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMYND8 grouped by ADAMTS7-low versus ADAMTS7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS7→partner) and Y-score (partner→ADAMTS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZMYND8 →	-0.791	-2.278	<.001	.001	3	2
LARGE_INTESTINE	CLUAP1 →	+0.559	+2.584	.002	.002	3	2
LARGE_INTESTINE	INTS9 →	+0.526	+3.169	.001	.006	3	2
LARGE_INTESTINE	DDX49 →	+0.452	+2.000	<.001	.009	3	2
LARGE_INTESTINE	PMP22 →	+1.184	+1.850	.004	.006	3	2
LARGE_INTESTINE	UFSP2 →	+0.452	+3.252	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,472 associations by consensus.

ZMYND8 by ADAMTS7 expression — LARGE_INTESTINE

Explore this box plot interactively →