ADAMTS5

Across TCGA patient cohorts, ADAMTS5 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,477 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ADAMTS5-associated proteins across cancer lineages are TIMP2, PDLIM3, and AEBP1. Each is linked with ADAMTS5 in more than 8 cancer types. Because this analysis shows association rather than direction, both ADAMTS5-to-partner and partner-to-ADAMTS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAMTS5 versus TIMP2 in OV, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS5→partner) and Y-score (partner→ADAMTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMP2 →	+0.658	+0.838	<.001	.008	3	9
HNSC	PDLIM3 →	+1.048	+0.668	<.001	.001	3	9
OV	AEBP1 →	+0.806	+1.070	<.001	<.001	3	9
BRCA	SRPX2 →	+1.001	+0.952	<.001	<.001	3	8
UCEC	ACTN1 →	+0.724	+0.976	<.001	<.001	3	8
CCRCC	PDLIM5 →	+0.746	+0.806	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,477 associations by consensus.

ADAMTS5 vs TIMP2 — OV

Explore this scatter interactively →