ADAMTS5

Across TCGA patient cohorts, ADAMTS5 protein abundance is significantly associated with the RNA expression of many other genes, with 3,050 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ADAMTS5-associated genes across cancer lineages are FLT1, SGCD, and ELP4. Each is linked with ADAMTS5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS5-to-partner and partner-to-ADAMTS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAMTS5 versus FLT1 in OV, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS5→partner) and Y-score (partner→ADAMTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FLT1 →	+0.723	+0.718	.001	<.001	3	3
OV	SGCD →	+0.988	+0.604	.007	.007	3	3
CCRCC	ELP4 →	-0.399	-0.768	.008	.005	3	3
GBM	FKBP10 →	+1.236	+1.171	.006	.001	3	3
OV	LAMA4 →	+1.031	+0.708	.001	.001	2	3
OV	ENOX1 →	+0.899	+0.628	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,050 associations by consensus.

ADAMTS5 vs FLT1 — OV

Explore this scatter interactively →