ADAMTS5

Across TCGA cell cohorts, ADAMTS5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,990 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAMTS5-associated GO terms across cancer lineages are RNA localization, Biological process involved in interaction with symbiont, and Angiogenesis. Each is linked with ADAMTS5 in more than 8 cancer types. Because this analysis shows association rather than direction, both ADAMTS5-to-partner and partner-to-ADAMTS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA localization grouped by ADAMTS5-low versus ADAMTS5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS5→partner) and Y-score (partner→ADAMTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNA localization →	+0.058	+0.552	.001	.005	3	9
SOFT_TISSUE	Biological process involved in interaction with symbiont →	+0.154	+2.396	<.001	<.001	3	8
BONE	Angiogenesis →	+0.125	+1.720	<.001	.003	3	8
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.074	+1.733	<.001	.001	3	8
BONE	Positive regulation of cytoskeleton organization →	+0.066	+1.775	<.001	.002	3	7
BONE	Positive regulation of focal adhesion assembly →	+0.221	+1.995	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,990 associations by consensus.

RNA localization by ADAMTS5 expression — SKIN

Explore this box plot interactively →