ADAMTS5

Across TCGA cell cohorts, ADAMTS5 mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS5-associated genes across cancer lineages are HTN1, CHRNB4, and RPL34. Each is linked with ADAMTS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS5-to-partner and partner-to-ADAMTS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN1 grouped by ADAMTS5-low versus ADAMTS5-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS5→partner) and Y-score (partner→ADAMTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HTN1 →	+0.050	+5.000	<.001	.005	3	2
BLOOD_Lymphoma	CHRNB4 →	+0.359	+3.307	<.001	.008	3	2
LARGE_INTESTINE	RPL34 →	+0.596	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	TGOLN2 →	-0.577	-2.764	.004	.001	3	2
LARGE_INTESTINE	BCAP29 →	-0.482	-2.072	.005	.008	3	2
KIDNEY	KRTAP19-1 →	+0.033	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

HTN1 by ADAMTS5 expression — KIDNEY

Explore this box plot interactively →