ADAMTS3

Across TCGA pan-cancer cohorts, ADAMTS3 Mutation is linked to patient survival in 15 of 34 cancer types, making it a survival-associated ADAMTS3 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ADAMTS3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

KIRP, ESCA, and READ are the cancer types where ADAMTS3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.141	0.904	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.305	0.716	<.001	26	view →
READ	OS	Median	II,III,IV	0.318	0.845	.008	15	view →
LIHC	DFS	Median	II,III,IV	0.109	0.431	.011	15	view →
UCEC	DFS	Median	All	0.935	0.614	.003	14	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
OV	DFS	Median	II,III,IV	0.204	0.541	.017	12	view →
LGG	OS	Median	All	0.221	0.889	<.001	6	view →
STAD	OS	Median	IV	0.358	0.564	.016	6	view →
LUAD	OS	Median	All	0.567	0.837	.023	6	view →
LUSC	DFS	Median	III,IV	0.227	0.523	.030	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

ADAMTS3–KIRP (OS)

Open the KIRP breakdown →