ADAMTS20

Across TCGA pan-cancer cohorts, ADAMTS20 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ADAMTS20 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ADAMTS20 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ADAMTS20 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, READ, and KIRP are the cancer types where ADAMTS20 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.835	0.620	.001	32	view →
READ	OS	Median	III,IV	0.274	0.757	<.001	21	view →
KIRP	DFS	Median	All	0.016	0.920	<.001	12	view →
COAD	OS	Median	II,III,IV	0.405	0.793	.001	12	view →
PRAD	DFS	Median	All	0.637	0.887	.009	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
LIHC	DFS	Median	III,IV	0.123	0.345	.017	3	view →
SKCM	DFS	Median	IV	0.040	0.432	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ADAMTS20–UCEC (DFS)

Open the UCEC breakdown →