ADAMTS18

Across TCGA pan-cancer cohorts, ADAMTS18 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADAMTS18 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ADAMTS18 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ADAMTS18 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, COAD, and CESC are the cancer types where ADAMTS18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.978	0.601	<.001	34	view →
COAD	DFS	Median	III,IV	0.130	0.616	.006	7	view →
CESC	OS	Median	IV	0.095	0.592	.004	6	view →
LUSC	DFS	Median	All	0.873	0.749	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ADAMTS18–UCEC (DFS)

Open the UCEC breakdown →