ADAMTS18

Across TCGA patient cohorts, ADAMTS18 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS18-associated genes across cancer lineages are Rad50, PKC-b-II_pS660, and STAT3_pY705. Each is linked with ADAMTS18 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTS18-to-partner and partner-to-ADAMTS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ADAMTS18-low versus ADAMTS18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS18→partner) and Y-score (partner→ADAMTS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.191	-1.637	.007	.001	3	5
LUSC	PKC-b-II_pS660 →	-0.225	-1.668	.044	.021	3	4
UCEC	STAT3_pY705 →	-0.444	-2.000	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.073	+2.815	<.001	.001	2	5
STAD	Cyclin-E1 →	+0.443	+2.000	.027	.030	3	3
LUAD	INPP4B →	-0.387	-3.683	.040	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Rad50 by ADAMTS18 expression — UCEC

Explore this box plot interactively →