ADAMTS18

Across TCGA cell cohorts, ADAMTS18 mutation is significantly associated with the RNA expression of many other genes, with 544 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS18-associated genes across cancer lineages are PRR20B, PRR20A, and PRR20D. Each is linked with ADAMTS18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS18-to-partner and partner-to-ADAMTS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR20B grouped by ADAMTS18-low versus ADAMTS18-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS18→partner) and Y-score (partner→ADAMTS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRR20B →	+0.032	+4.977	<.001	.002	3	2
SOFT_TISSUE	PRR20A →	+0.032	+4.977	<.001	.002	3	2
SOFT_TISSUE	PRR20D →	+0.032	+4.977	<.001	.002	3	2
SOFT_TISSUE	PRR20E →	+0.032	+4.977	<.001	.002	3	2
LARGE_INTESTINE	ACBD5 →	+0.723	+3.321	.001	.002	3	2
LARGE_INTESTINE	OGFRL1 →	+1.084	+3.321	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 544 associations by consensus.

PRR20B by ADAMTS18 expression — SOFT_TISSUE

Explore this box plot interactively →