ADAMTS13

Across TCGA patient cohorts, ADAMTS13 protein abundance is significantly associated with the RNA expression of many other genes, with 1,364 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ADAMTS13-associated genes across cancer lineages are NUP85, SRGN, and FFAR2. Each is linked with ADAMTS13 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS13-to-partner and partner-to-ADAMTS13 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAMTS13 versus NUP85 in LSCC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS13→partner) and Y-score (partner→ADAMTS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NUP85 →	-0.654	-0.297	<.001	.002	3	2
HNSC	SRGN →	+2.034	+2.053	.004	.005	3	2
HNSC	FFAR2 →	+1.810	+2.263	.005	<.001	3	2
CCRCC	SLC14A1 →	+1.008	+0.628	.001	<.001	3	2
CCRCC	F5 →	+2.558	+0.732	.002	.002	3	2
HNSC	TRAV35 →	+1.995	+2.224	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,364 associations by consensus.

ADAMTS13 vs NUP85 — LSCC

Explore this scatter interactively →