ADAMTS13

Across TCGA patient cohorts, ADAMTS13 mutation is significantly associated with the RNA expression of many other genes, with 4,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS13-associated genes across cancer lineages are ISOC1, RAD51, and SNRPD3. Each is linked with ADAMTS13 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAMTS13-to-partner and partner-to-ADAMTS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ISOC1 grouped by ADAMTS13-low versus ADAMTS13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS13→partner) and Y-score (partner→ADAMTS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ISOC1 →	+0.409	+1.354	.003	.007	3	6
UCEC	RAD51 →	+0.724	+1.836	<.001	<.001	3	5
COAD	SNRPD3 →	+0.259	+2.100	.007	.003	3	4
COAD	R3HCC1 →	+0.420	+3.867	.001	<.001	3	4
UCEC	ZWINT →	+0.614	+1.825	<.001	<.001	3	4
UCEC	TTI2 →	+0.422	+1.850	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,709 associations by consensus.

ISOC1 by ADAMTS13 expression — UCEC

Explore this box plot interactively →