ADAMTS13

Across TCGA cell cohorts, ADAMTS13 mutation is significantly associated with the RNA expression of many other genes, with 642 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS13-associated genes across cancer lineages are CCDC138, PSMC3IP, and MAPK8. Each is linked with ADAMTS13 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS13-to-partner and partner-to-ADAMTS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC138 grouped by ADAMTS13-low versus ADAMTS13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS13→partner) and Y-score (partner→ADAMTS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC138 →	+0.514	+1.850	.003	.006	3	3
BLOOD_Leukemia	PSMC3IP →	+0.686	+3.489	.001	.001	3	3
LARGE_INTESTINE	MAPK8 →	+0.529	+2.023	.008	.002	3	2
LARGE_INTESTINE	TRIM37 →	+0.549	+2.364	.002	<.001	3	2
LARGE_INTESTINE	EPM2A →	+0.411	+2.584	.004	.002	3	2
LARGE_INTESTINE	DENND10 →	+0.566	+1.850	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 642 associations by consensus.

CCDC138 by ADAMTS13 expression — LARGE_INTESTINE

Explore this box plot interactively →