ADAMTS12

Across TCGA patient cohorts, ADAMTS12 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ADAMTS12-associated genes across cancer lineages are PKC-b-II_pS660, Caspase-7-cleavedD198, and PCNA. Each is linked with ADAMTS12 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTS12-to-partner and partner-to-ADAMTS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by ADAMTS12-low versus ADAMTS12-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS12→partner) and Y-score (partner→ADAMTS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-b-II_pS660 →	-0.416	-2.459	.001	.018	3	5
STAD	Caspase-7-cleavedD198 →	+0.747	+2.415	.005	.003	3	5
STAD	PCNA →	+0.335	+3.321	.001	.008	3	4
STAD	cIAP →	+0.149	+3.087	.004	<.001	3	4
STAD	4E-BP1 →	+0.384	+3.584	<.001	.002	3	4
BLCA	PKC-a_pS657 →	-0.302	-1.700	.006	.040	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

PKC-b-II_pS660 by ADAMTS12 expression — STAD

Explore this box plot interactively →