ADAMTS12

Across TCGA cell cohorts, ADAMTS12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,421 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAMTS12-associated GO terms across cancer lineages are Dentinogenesis, Negative regulation of plasminogen activation, and PML body organization. Each is linked with ADAMTS12 in more than 11 cancer types. Because this analysis shows association rather than direction, both ADAMTS12-to-partner and partner-to-ADAMTS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dentinogenesis grouped by ADAMTS12-low versus ADAMTS12-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS12→partner) and Y-score (partner→ADAMTS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Dentinogenesis →	+1.860	+2.359	<.001	<.001	3	12
BONE	Negative regulation of plasminogen activation →	+1.191	+3.105	<.001	<.001	3	11
URINARY_TRACT	PML body organization →	+0.178	+2.347	.001	.002	3	11
OESOPHAGUS	Positive regulation of intracellular transport →	+0.073	+1.251	<.001	.007	3	11
BREAST	Maintenance of protein location in cell →	+0.103	+1.973	<.001	.001	3	11
BONE	Substrate adhesion-dependent cell spreading →	+0.179	+2.352	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,421 associations by consensus.

Dentinogenesis by ADAMTS12 expression — BONE

Explore this box plot interactively →