ADAM9

Across TCGA patient cohorts, ADAM9 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM9-associated genes across cancer lineages are ATM, p70-S6K, and Rab25. Each is linked with ADAM9 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM9-to-partner and partner-to-ADAM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADAM9-low versus ADAM9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM9→partner) and Y-score (partner→ADAM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.812	-3.000	<.001	.035	3	4
UCEC	p70-S6K →	+0.169	+2.441	.029	.001	3	2
UCEC	Rab25 →	-0.510	-1.906	<.001	.016	3	2
UCEC	ASNS →	+0.520	+2.000	<.001	.030	3	2
UCEC	c-Met_pY1235 →	+0.089	+3.087	.002	<.001	3	2
UCEC	Cyclin-E2 →	+0.216	+3.710	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by ADAM9 expression — COAD

Explore this box plot interactively →