ADAM9

Across TCGA cell cohorts, ADAM9 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,708 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAM9-associated GO terms across cancer lineages are Regulation of macrophage fusion, Positive regulation of macrophage fusion, and Integrin-mediated signaling pathway. Each is linked with ADAM9 in more than 19 cancer types. Because this analysis shows association rather than direction, both ADAM9-to-partner and partner-to-ADAM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macrophage fusion grouped by ADAM9-low versus ADAM9-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM9→partner) and Y-score (partner→ADAM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of macrophage fusion →	+0.322	+1.200	<.001	<.001	3	20
LUNG_SCLC	Positive regulation of macrophage fusion →	+0.322	+1.200	<.001	<.001	3	20
BONE	Integrin-mediated signaling pathway →	+0.221	+1.656	<.001	<.001	3	15
LARGE_INTESTINE	Caveola assembly →	+0.223	+1.350	<.001	<.001	3	14
BONE	Positive regulation of protein exit from endoplasmic reticulum →	+0.122	+1.798	<.001	<.001	3	14
BONE	Positive regulation of cell-substrate adhesion →	+0.137	+1.591	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,708 associations by consensus.

Regulation of macrophage fusion by ADAM9 expression — LUNG_SCLC

Explore this box plot interactively →