ADAM9

Across TCGA cell cohorts, ADAM9 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM9-associated genes across cancer lineages are OR6N1, GSG1L2, and GFRAL. Each is linked with ADAM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM9-to-partner and partner-to-ADAM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6N1 grouped by ADAM9-low versus ADAM9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM9→partner) and Y-score (partner→ADAM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR6N1 →	+0.272	+5.060	<.001	.001	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
LUNG_NSCLC_LUAD	GFRAL →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KIR2DL3 →	+0.298	+4.371	<.001	.005	3	1
LARGE_INTESTINE	ZNF831 →	+0.013	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR6N1 by ADAM9 expression — BLOOD_Leukemia

Explore this box plot interactively →