ADAM8

Across TCGA patient cohorts, ADAM8 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,779 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADAM8-associated proteins across cancer lineages are NCF2, ARHGAP45, and CYBB. Each is linked with ADAM8 in more than 9 cancer types. Because this analysis shows association rather than direction, both ADAM8-to-partner and partner-to-ADAM8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADAM8 versus NCF2 in GBM, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM8→partner) and Y-score (partner→ADAM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF2 →	+0.924	+1.578	<.001	<.001	3	10
OV	ARHGAP45 →	+0.523	+1.026	.004	.001	3	10
COAD	CYBB →	+0.540	+0.799	<.001	<.001	3	9
CCRCC	AMPD3 →	+0.489	+0.833	<.001	<.001	3	9
OV	ITGB2 →	+0.676	+1.073	.001	<.001	3	9
GBM	LCP2 →	+0.519	+1.215	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,779 associations by consensus.

ADAM8 vs NCF2 — GBM

Explore this scatter interactively →