ADAM8

Across TCGA patient cohorts, ADAM8 mutation is significantly associated with the RNA expression of many other genes, with 2,162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM8-associated genes across cancer lineages are BUB3, SFXN1, and TIPIN. Each is linked with ADAM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM8-to-partner and partner-to-ADAM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by ADAM8-low versus ADAM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM8→partner) and Y-score (partner→ADAM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.365	+1.923	.002	.003	3	3
UCEC	SFXN1 →	+0.473	+2.758	<.001	<.001	3	3
UCEC	TIPIN →	+0.501	+2.513	<.001	<.001	3	3
UCEC	TIMM21 →	+0.429	+2.502	<.001	.001	3	3
UCEC	TXNL1 →	+0.338	+2.286	.002	.005	3	3
COAD	GOT1 →	+0.707	+3.486	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,162 associations by consensus.

BUB3 by ADAM8 expression — UCEC

Explore this box plot interactively →