ADAM8

Across TCGA patient cohorts, ADAM8 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM8-associated genes across cancer lineages are Cyclin-B1, A-Raf_pS299, and ERK2. Each is linked with ADAM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM8-to-partner and partner-to-ADAM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ADAM8-low versus ADAM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM8→partner) and Y-score (partner→ADAM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.464	+2.584	.021	.010	3	2
UCEC	A-Raf_pS299 →	-0.124	-2.000	.003	.030	3	1
UCEC	ERK2 →	+0.182	+1.906	.008	.015	3	1
UCEC	Fibronectin →	-0.236	-2.308	.047	.033	3	1
UCEC	GATA6 →	-0.133	-1.577	.017	.018	3	1
UCEC	JNK2 →	+0.189	+2.196	.008	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cyclin-B1 by ADAM8 expression — UCEC

Explore this box plot interactively →