ADAM8

Across TCGA cell cohorts, ADAM8 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM8-associated genes across cancer lineages are SLC22A6, CLEC6A, and TLE7. Each is linked with ADAM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM8-to-partner and partner-to-ADAM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A6 grouped by ADAM8-low versus ADAM8-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM8→partner) and Y-score (partner→ADAM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC22A6 →	+0.163	+5.029	<.001	.006	3	1
LUNG_SCLC	CLEC6A →	+0.126	+5.029	<.001	.006	3	1
LUNG_SCLC	TLE7 →	+0.030	+5.643	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	ASB10 →	+0.022	+4.736	<.001	.009	3	1
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1
LARGE_INTESTINE	KRT85 →	+0.473	+3.823	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

SLC22A6 by ADAM8 expression — LUNG_SCLC

Explore this box plot interactively →