ADAM6

Across TCGA pan-cancer cohorts, ADAM6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ADAM6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ADAM6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAM6 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.

LUAD and LIHC are the cancer types where ADAM6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.010	.036	2	view →
LIHC	All	All	−0.002	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

ADAM6–LUAD

Open the LUAD breakdown →