ADAM33

Across TCGA patient cohorts, ADAM33 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM33-associated genes across cancer lineages are FOXO3a, Cyclin-B1, and Src. Each is linked with ADAM33 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM33-to-partner and partner-to-ADAM33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by ADAM33-low versus ADAM33-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM33→partner) and Y-score (partner→ADAM33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a →	-0.099	-3.000	.048	.035	3	2
UCEC	Cyclin-B1 →	+0.509	+2.459	.024	.019	3	2
SKCM	Src →	-0.213	-1.874	.032	.049	3	1
SKCM	Bcl-2 →	-0.350	-3.321	.024	.009	3	1
SKCM	Bim →	-0.302	-3.169	.009	.018	3	1
UCEC	Ku80 →	+0.226	+1.498	.017	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FOXO3a by ADAM33 expression — SKCM

Explore this box plot interactively →