ADAM33

Across TCGA cell cohorts, ADAM33 mutation is significantly associated with the mutation status of many other genes, with 4,375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM33-associated genes across cancer lineages are TNRC6A, KLHDC7A, and SUPT5H. Each is linked with ADAM33 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAM33-to-partner and partner-to-ADAM33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6A grouped by ADAM33-low versus ADAM33-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM33→partner) and Y-score (partner→ADAM33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TNRC6A →	+5.345	+4.632	<.001	<.001	1	6
LARGE_INTESTINE	KLHDC7A →	+2.146	+2.321	.008	.008	1	5
OVARY	SUPT5H →	+3.930	+3.632	.003	.003	1	5
SKIN	TBC1D32 →	+4.392	+4.392	.009	.009	1	5
LUNG_NSCLC_LUAD	TCF3 →	+5.339	+4.772	.004	.004	1	4
CNS	FAT3 →	+2.740	+4.237	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,375 associations by consensus.

TNRC6A by ADAM33 expression — OVARY

Explore this box plot interactively →