ADAM29

Across TCGA patient cohorts, ADAM29 mutation is significantly associated with the RNA expression of many other genes, with 6,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM29-associated genes across cancer lineages are MRPL37, PPIP5K1, and UQCRH. Each is linked with ADAM29 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM29-to-partner and partner-to-ADAM29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL37 grouped by ADAM29-low versus ADAM29-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM29→partner) and Y-score (partner→ADAM29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL37 →	+0.465	+2.039	<.001	<.001	3	4
UCEC	PPIP5K1 →	+0.360	+1.702	<.001	<.001	3	4
UCEC	UQCRH →	+0.571	+1.523	.006	<.001	3	4
UCEC	TRAM2-AS1 →	+0.300	+2.290	.004	<.001	3	4
UCEC	LINC00987 →	-0.288	-1.408	.003	.004	3	4
HNSC	RNA5SP391 →	+0.070	+4.906	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,275 associations by consensus.

MRPL37 by ADAM29 expression — UCEC

Explore this box plot interactively →