ADAM29

Across TCGA patient cohorts, ADAM29 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM29-associated genes across cancer lineages are Caspase-7-cleavedD198, Paxillin, and Axl. Each is linked with ADAM29 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM29-to-partner and partner-to-ADAM29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADAM29-low versus ADAM29-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM29→partner) and Y-score (partner→ADAM29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.864	+2.186	.005	.032	3	3
COAD	Paxillin →	-0.278	-2.321	.046	.033	3	2
COAD	Axl →	-0.228	-3.303	.031	.009	3	2
UCEC	4E-BP1 →	+0.344	+3.087	<.001	<.001	3	2
UCEC	eIF4E →	+0.210	+2.459	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.572	+2.221	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Caspase-7-cleavedD198 by ADAM29 expression — COAD

Explore this box plot interactively →