ADAM28

Across TCGA patient cohorts, ADAM28 mutation is significantly associated with the RNA expression of many other genes, with 4,110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM28-associated genes across cancer lineages are MEX3D, FBXO7, and VCPKMT. Each is linked with ADAM28 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM28-to-partner and partner-to-ADAM28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEX3D grouped by ADAM28-low versus ADAM28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM28→partner) and Y-score (partner→ADAM28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEX3D →	+0.627	+2.524	<.001	<.001	3	4
UCEC	FBXO7 →	+0.378	+1.960	.001	<.001	3	3
UCEC	VCPKMT →	+0.357	+2.169	.007	.003	3	3
UCEC	SNW1 →	+0.413	+2.284	.003	<.001	3	3
UCEC	PLEKHA8 →	+0.418	+2.671	<.001	<.001	3	3
UCEC	FOXM1 →	+0.709	+2.008	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,110 associations by consensus.

MEX3D by ADAM28 expression — UCEC

Explore this box plot interactively →