ADAM28

Across TCGA cell cohorts, ADAM28 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,710 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM28-associated GO terms across cancer lineages are Regulation of cytokine-mediated signaling pathway, Protein folding in endoplasmic reticulum, and Response to interleukin-1. Each is linked with ADAM28 in more than 9 cancer types. Because this analysis shows association rather than direction, both ADAM28-to-partner and partner-to-ADAM28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytokine-mediated signaling pathway grouped by ADAM28-low versus ADAM28-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM28→partner) and Y-score (partner→ADAM28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of cytokine-mediated signaling pathway →	+0.052	+0.738	.004	.003	3	10
LUNG_NSCLC_LUAD	Protein folding in endoplasmic reticulum →	+0.111	+1.659	<.001	<.001	3	10
PANCREAS	Response to interleukin-1 →	+0.087	+2.292	<.001	<.001	3	9
URINARY_TRACT	Negative regulation of response to endoplasmic reticulum stress →	+0.126	+1.675	<.001	.008	3	9
OVARY	Regulation of response to cytokine stimulus →	+0.052	+0.662	.003	.009	3	9
URINARY_TRACT	Positive regulation of proteolysis →	+0.109	+2.436	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,710 associations by consensus.

Regulation of cytokine-mediated signaling pathway by ADAM28 expression — OVARY

Explore this box plot interactively →