ADAM28

Across TCGA cell cohorts, ADAM28 mutation is significantly associated with the RNA expression of many other genes, with 1,199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM28-associated genes across cancer lineages are DESI1, P3H3, and RGS10. Each is linked with ADAM28 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM28-to-partner and partner-to-ADAM28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by ADAM28-low versus ADAM28-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM28→partner) and Y-score (partner→ADAM28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.409	+3.321	.006	.003	3	2
LARGE_INTESTINE	P3H3 →	+1.387	+2.743	.004	.001	3	2
LARGE_INTESTINE	RGS10 →	+0.918	+2.043	.002	.008	3	2
LARGE_INTESTINE	PPIL6 →	+0.692	+3.169	.001	.006	3	2
LARGE_INTESTINE	H4C15 →	-1.085	-2.657	<.001	.002	3	2
LARGE_INTESTINE	ULK2 →	+1.005	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,199 associations by consensus.

DESI1 by ADAM28 expression — LARGE_INTESTINE

Explore this box plot interactively →