ADAM2

Across TCGA patient cohorts, ADAM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,765 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ADAM2-associated GO terms across cancer lineages are Regulation of DNA repair, Endoplasmic reticulum to Golgi vesicle-mediated transport, and Cytokinesis. Each is linked with ADAM2 in more than 9 cancer types. Because this analysis shows association rather than direction, both ADAM2-to-partner and partner-to-ADAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by ADAM2-low versus ADAM2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM2→partner) and Y-score (partner→ADAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of DNA repair →	+0.064	+0.264	<.001	.001	3	10
ESCA	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.064	+0.196	<.001	.003	3	10
ESCA	Cytokinesis →	+0.067	+0.210	<.001	.002	3	10
STAD	Mitochondrial respiratory chain complex assembly →	+0.069	+0.163	<.001	<.001	3	9
STAD	Macromolecule methylation →	+0.056	+0.143	<.001	<.001	3	9
STAD	Vesicle targeting, to, from or within Golgi →	+0.059	+0.144	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,765 associations by consensus.

Regulation of DNA repair by ADAM2 expression — ESCA

Explore this box plot interactively →