ADAM2

Across TCGA patient cohorts, ADAM2 mutation is significantly associated with the RNA expression of many other genes, with 3,517 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM2-associated genes across cancer lineages are MLX, RFC5, and AUP1. Each is linked with ADAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM2-to-partner and partner-to-ADAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLX grouped by ADAM2-low versus ADAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM2→partner) and Y-score (partner→ADAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLX →	+0.466	+2.441	<.001	<.001	3	3
UCEC	RFC5 →	+0.546	+1.934	<.001	.002	3	3
UCEC	AUP1 →	+0.289	+2.354	<.001	<.001	3	3
UCEC	GOT1 →	+0.324	+2.386	.007	<.001	3	3
UCEC	SLC66A2 →	+0.343	+2.243	.006	.005	3	3
UCEC	HROB →	+0.499	+2.595	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,517 associations by consensus.

MLX by ADAM2 expression — UCEC

Explore this box plot interactively →