ADAM2

Across TCGA patient cohorts, ADAM2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM2-associated genes across cancer lineages are TFRC, Cyclin-B1, and Di-Ras3. Each is linked with ADAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM2-to-partner and partner-to-ADAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ADAM2-low versus ADAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM2→partner) and Y-score (partner→ADAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.389	+2.000	.034	.029	3	3
UCEC	Cyclin-B1 →	+0.790	+3.807	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.121	-2.102	.018	.016	3	3
LUAD	C-Raf_pS338 →	+0.107	+3.169	.023	.018	3	2
UCEC	C-Raf →	+0.217	+2.087	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.348	-2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

TFRC by ADAM2 expression — UCEC

Explore this box plot interactively →