ADAM2

Across TCGA cell cohorts, ADAM2 RNA expression is significantly associated with the mutation status of many other genes, with 127 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ADAM2-associated genes across cancer lineages are SEMA6C, COL20A1, and WDFY3. Each is linked with ADAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM2-to-partner and partner-to-ADAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA6C grouped by ADAM2-low versus ADAM2-high in OVARY.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM2→partner) and Y-score (partner→ADAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SEMA6C →	+2.675	+0.350	.006	.002	3	3
URINARY_TRACT	COL20A1 →	+4.217	+0.132	.005	<.001	3	2
URINARY_TRACT	WDFY3 →	+4.217	+0.132	.005	<.001	3	2
CNS	TICAM1 →	+4.169	+0.027	.008	<.001	3	2
CNS	DZIP3 →	+4.169	+0.027	.008	<.001	3	2
SKIN	STAB1 →	+3.700	+0.002	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

SEMA6C by ADAM2 expression — OVARY

Explore this box plot interactively →