ADAM2

Across TCGA cell cohorts, ADAM2 mutation is significantly associated with the RNA expression of many other genes, with 393 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM2-associated genes across cancer lineages are PRL, C9orf92, and ASZ1. Each is linked with ADAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM2-to-partner and partner-to-ADAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRL grouped by ADAM2-low versus ADAM2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM2→partner) and Y-score (partner→ADAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRL →	+0.019	+3.584	<.001	.003	3	2
LUNG_SCLC	C9orf92 →	+0.466	+3.523	<.001	.008	3	2
BLOOD_Leukemia	ASZ1 →	+0.087	+2.982	.002	.007	3	2
BLOOD_Leukemia	CFHR2 →	+0.174	+4.124	<.001	<.001	3	2
LUNG_NSCLC_LUAD	PRR30 →	+0.011	+3.189	<.001	.007	3	2
LUNG_NSCLC_LUSC	SLC17A3 →	+0.032	+3.514	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 393 associations by consensus.

PRL by ADAM2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →