Across TCGA pan-cancer cohorts, ADAM1B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ADAM1B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADAM1B RNA is repressed in tumor relative to normal tissue. In most cancer types ADAM1B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.
KIRC, THCA, and LUAD are the cancer types where ADAM1B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM1B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.