ADAM19

Across TCGA patient cohorts, ADAM19 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM19-associated genes across cancer lineages are Ku80, ASNS, and 4E-BP1. Each is linked with ADAM19 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM19-to-partner and partner-to-ADAM19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ADAM19-low versus ADAM19-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM19→partner) and Y-score (partner→ADAM19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Ku80 →	+0.307	+2.349	.047	.019	3	3
UCEC	ASNS →	+0.404	+1.736	<.001	.005	3	3
UCEC	4E-BP1 →	+0.406	+1.954	<.001	<.001	3	3
COAD	C-Raf →	+0.166	+3.178	.021	.010	3	3
UCEC	eIF4E →	+0.221	+2.192	<.001	<.001	3	2
LUAD	Caveolin-1 →	-0.872	-3.321	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Ku80 by ADAM19 expression — LUSC

Explore this box plot interactively →